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Hi Mona:
There are three answers to your ques­tion:

1. Con­di­tion your­self for high alti­tude using the alti­tude pre­pare pro­to­col start­ing at least 2 weeks before trav­el
2. Use a trav­el cock­tail of B‑Vitamins dur­ing trav­el to opti­mize oxy­gen trans­fer dur­ing the trav­el expe­ri­ence, B1, B6, B‑12, Mag­ne­sium Oro­tate & Vit­a­min C
3. Avoid dehy­dra­tion — con­cen­trat­ed blood plas­ma pre­vents oxy­gen from dis­solv­ing into plas­ma and trig­gers inflam­ma­tion — Pro­to­col 1 has a strong effect of improv­ing cel­lu­lar hydra­tion metab­o­lism well before trav­el. Urine should be light and copi­ous a week before, dur­ing and after trav­el

Hope this helps. The trav­el stress expe­ri­ence often is a major cul­prit set­ting the stage for alti­tude sick­ness, as is the ten­den­cy for to have a few extra drinks on vaca­tion. Both of these ele­ments con­tribute to vul­ner­a­bil­i­ty. Option 1 — usu­al­ly improves metab­o­lism enough to pre­vent issues.
Mark